Abstract
A series of compounds having a piperazine moiety variously linked to the benzothiazine nucleus were synthesized and evaluated for their in vitro alpha-adrenoceptor affinity by radioligand receptor binding assays. Some compounds bearing a oxyalkyl-(2-methoxyphenyl)piperazine side chain were good alpha1-adrenoreceptor ligands.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic beta-Antagonists / chemical synthesis
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Adrenergic beta-Antagonists / pharmacology
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Animals
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Antihypertensive Agents / chemical synthesis*
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Antihypertensive Agents / pharmacology
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Brain Chemistry / drug effects
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Chemical Phenomena
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Chemistry, Physical
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In Vitro Techniques
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Ligands
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Lung / drug effects
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Lung / metabolism
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Magnetic Resonance Spectroscopy
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Myocardium / metabolism
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Piperazines / chemical synthesis*
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Piperazines / pharmacology
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Radioligand Assay
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Rats
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Receptors, Adrenergic, alpha-1 / drug effects
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Receptors, Adrenergic, alpha-2 / drug effects
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Receptors, Adrenergic, beta-1 / drug effects
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Receptors, Adrenergic, beta-2 / drug effects
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Thiazines / chemical synthesis*
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Thiazines / pharmacology
Substances
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Adrenergic beta-Antagonists
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Antihypertensive Agents
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Ligands
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Piperazines
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Receptors, Adrenergic, alpha-1
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Receptors, Adrenergic, alpha-2
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Receptors, Adrenergic, beta-1
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Receptors, Adrenergic, beta-2
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Thiazines